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STUDY: Mucociliary respiratory tract dysfunction with e-cigarettes

STUDY: Mucociliary respiratory tract dysfunction with e-cigarettes

According to new research published online in the American Thoracic Society, the e-cigarette containing nicotine seems to hinder the elimination of the mucous membranes of the respiratory tract ...


Matthias Salathe - University of Kansas Medical

E-CIGARETTE WITH NICOTINE SEEMS TO CAUSE MUCOCILIARY DYSFUNCTION!


The study " The e-cigarette causes mucociliary dysfunction of the respiratory tract preferentially via the TRPA1 receptors Has been published online in the American Thoracic Society by a team of researchers from the University of Kansas, the University of Miami and Mt.

Sinai Medical Center in Miami Beach reported that exposure of human airway cells to e-cigarette vapor containing nicotine in culture resulted in a decrease in the ability of mucus or phlegm to move across the surface. . This phenomenon is called " mucociliary dysfunction". The researchers report the same finding in vivo in sheep, whose airways resemble those of humans exposed to e-cigarette vapor.

« This study is based on our team's research on the influence of tobacco smoke on the clearance of mucus from the respiratory tract." , said Matthias Salathe, author, director of internal medicine and professor of pulmonary medicine and intensive care at the University of Kansas Medical. Center. " The question was whether vaping with nicotine had negative effects on the ability to clear respiratory tract secretions similar to tobacco smoke. »

Mucociliary dysfunction is a hallmark of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Specifically, the study found that vaping with nicotine altered the frequency of ciliary beats, dehydrated airway fluid, and made mucus more viscous or sticky. These changes make it more difficult to defend the bronchi, the main passageways of the lungs, against infection and injury.

Researchers noted that a recent report found that never-smoker young e-cigarette users were at an increased risk of developing chronic bronchitis, a condition characterized by chronic phlegm production that is also seen in people with disabilities. tobacco smokers.

Dr Salathe said the recently published data not only corroborated the previous clinical report, but also helped explain it. A single session of vaping can release more nicotine into the airways than burning a cigarette. Additionally, according to Dr. Salathe, absorption into the blood is lower, possibly exposing the airways to high concentrations of nicotine for long periods of time.

The study also found that nicotine produced these negative effects by stimulating the potential of the transient ion channel receptor, ankyrin 1 (TRPA1). Blockade of TRPA1 reduced the effects of nicotine on clearance in cultured human cells and in sheep.

« The e-cigarette with nicotine is not harmless and at a minimum it increases the risk of chronic bronchitis. Says Dr Salathe. " Our study, along with others, could even question the value of e-cigarettes as a risk reduction approach for smokers. « 

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Passionate about journalism, I decided to join the editorial team of Vapoteurs.net in 2017 in order to mainly deal with vape news in North America (Canada, United States).