STUDY: Aromas used for the vape can increase the risk of heart disease

STUDY: Aromas used for the vape can increase the risk of heart disease

A new study conducted by researchers from the Stanford University School of Medicine states that certain flavors used for e-liquids may increase the risk of cardiovascular disease when inhaled. An assertion that may seem harmless to see far-fetched but that could have an importance in the future choice of legislation on the vape including the United States.


Scientists have studied the effect of e-liquids on cells called endothelial cells that line the inside of blood vessels. They found that when grown in the laboratory, endothelial cells exposed to e-liquids are less viable and show a significant increase in the level of molecules that promote DNA damage and thus cell death. These cells would also be less able to migrate into the body and participate in wound healing.

According to the researchers, the severity of the damage would be variable according to the aromas: cinnamon et menthol are those that have proven particularly harmful.

« So far, we had no data on how these e-liquids affect endothelial cells Explains the Pr Joseph Wu Stanford Cardiovascular Institute. " This study shows that e-cigarettes are not a safe alternative to conventional cigarettes. When we exposed the cells to six different flavors of liquids containing different levels of nicotine, we found significant damage. The cells were less viable in culture, and they began to exhibit symptoms of dysfunction. But endothelial cells are known to play a vital role in heart and cardiovascular health.
Although some studies suggest that electronic cigarettes generate fewer carcinogens for users than conventional cigarettes, possibly reducing the risk of cancer, the effect of their use on vascular health is unclear.

"We now know that they may also have other toxic effects on vascular function. - Pr Joseph Wu

On the subject, the French Federation of Cardiology in practice, " We are not familiar with the effects of the e-cigarette on the cardiovascular level. What is certain is that tobacco is growing platelet reactivity. That is, it promotes clot formation in the blood and promotes the occurrence of myocardial infarction. It is not known if the e-cigarette has the same cardiovascular effect, there are no studies on the subject. »
The researchers studied the effect of different common liquid flavors: fruit, tobacco, caramel and vanilla sweet tobacco, sweet caramel, cinnamon and menthol, with different levels of nicotine on the endothelial cells. In addition to the impact of the cinnamon and menthol flavors, they found that caramel and vanilla e-liquids also disrupted their growth, but in a less severe manner. " Some of the effects of e-liquid exposure depended on the concentration of nicotine but others such as decreased cell viability were independent, suggesting a combined effect of nicotine concentrations and flavors ", Say the researchers.

Finally, they compared nicotine levels in the blood serum of people who "vapote" with those who smoked traditional cigarettes. They found that the amounts of nicotine in the blood were similar between the two groups after smoking for 10 minutes at a constant rate.

« When you smoke a classic cigarette, you have an idea of ​​how many cigarettes you smoke "Says Professor Wu." But with the e-cigarette, it's easier to expose yourself to a higher level of nicotine over a shorter period. And we now know that they may also have other toxic effects on vascular function. »

The team of scientists therefore invites e-cigarette users to use it knowingly, realizing that chemicals can circulate in their bodies and harm their vascular health.

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About the Author

Passionate about journalism, I decided to join the editorial team of in 2017 in order to mainly deal with vape news in North America (Canada, United States).

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